ADCs and bioconjugates
Our scientists have extensive experience in providing services related to the synthesis and characterisation of antibody-drug conjugates (ADCs) and other bioconjugates. We have worked with a variety of highly potent payloads, as well as a selection of cleavable and non-cleavable linkers and spacers. We can also provide a number of different linker strategies in order to fine tune activity and stability in various media.
Our synthetic services related to ADC and bioconjugates include:
- Preparation and purification of ADCs and other bioconjugates
- Design and synthesis of payloads, spacers and linkers
- Modification of carbohydrates, including polysaccharides and glycoconjugates
- Preparation and purification of lipids and conjugates thereof
- Preparation and purification of fluorescent probes
Our analytical support methods include:
- High performance liquid chromatography (HPLC)
- Reversed-phase chromatography (RP)
- Size-exclusion chromatography (SEC)
- Hydrophobic interaction chromatography (HIC)
- Triple quadrupol mass spectrometry (MS TQ)
- Mass spectrometry quadrupole time-of-flight (MS QTOF)
- Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (Maldi-TOF MS)
- Nuclear magnetic resonance (NMR)
- Ultraviolet-visible light spectrophotometry (UV/Vis)
Additional characterisation and analyses are also available.